Predicting toxicity of chemicals: software beats animal testing

Testing for the Toxicity of Chemicals

(Sci. Tot. Environ. 43, 149 (1958)) Testing for the Toxicity of Chemicals with Tetrahymenapyriformis. YosHITADA YOsHIOKA, YOuKI OSE*, TAKAHIKO SATO A test was developed using Tetrahymena Pyn'formis in order to determine the toxicity of various chemicals. Pre-cultured T. Pyrifbrmis was exposed for 24h at 30aC to various concentrations of chemicals, and the number of T. Pyrifbrmis surviving were ...

The Historical Development of Animal Toxicity Testing

The ToxCast program for prioritizing toxicity testing of environmental chemicals.

The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predict potential for toxicity and prioritize limited testing resources toward chemicals that likely represent the greatest hazard to human health and the environment. This chemical prioritization research program,...

Toxicity testing in the 21st century beyond environmental chemicals.

After the publication of the report titled Toxicity Testing in the 21st Century - A Vision and a Strategy, many initiatives started to foster a major paradigm shift for toxicity testing - from apical endpoints in animal-based tests to mechanistic endpoints through delineation of pathways of toxicity (PoT) in human cell based systems. The US EPA has funded an important project to develop new hig...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN